Hyperspectral imaging is one of the recent technologies in the field of quality testing of pharmaceutical products. The present study describes the spectral behavior of two Active Pharmaceutical Ingredients (API) at photo and thermal stressed conditions and the contamination on the surface. We aim to study how the hyperspectral technique can measure the physical and chemical changes of pharmaceutical ingredients at stressed conditions. Multispectral and hyperspectral cameras were used for qualitative data collection of thousands of spectra. Results were compared with traditional UV and XRD methods. Implementation of such non-destroying, non-polluting, eco-friendly and fast technology will be useful in the pharmaceutical manufacturing, packing and reaction monitoring. Hyperspectral technology will be useful in the future space explorations for a better understanding of drug stability, safety, and effectiveness in space.